DEM

CFD-DEM study in the 20L explosion sphere

CFD-DEM study of the influence of the particle clump shape on the degree of agglomeration and de-agglomeration in the 20L explosion sphere

Multi-scale modeling of fluid bed granulation

Aligned with the FDA and pharmaceutical industry's efforts to implement the quality by design paradigm and incorporate design-based principles to both new and existing manufacturing processes, this work aims to move towards a predictive model-based analysis to establish a process design space linking critical process parameters and formulation properties to critical quality attributes.